Overview of Picked Chemical Compounds and Intermediates
Overview of Picked Chemical Compounds and Intermediates
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one. Pharmaceutical Intermediates
Bortezomib Acid Impurity: This can be an impurity associated with bortezomib, a proteasome inhibitor Employed in the procedure of several myeloma. Its synthesis or analyze is very important for making certain the purity and security of the drug.
Abiraterone Acetate Intermediate (CAS NO. 122111-01-7): A precursor within the synthesis of abiraterone acetate, a drug Employed in the therapy of prostate cancer by inhibiting androgen production.
Imatinib Intermediate (CAS NO. 152460-ten-one): A critical compound while in the synthesis of imatinib, a drug that targets particular varieties of cancer, including Continual myelogenous leukemia (CML).
Docetaxel Intermediate: A compound Utilized in the synthesis of docetaxel, a chemotherapy medication that treats several cancers which include breast, lung, and prostate cancer.
two. Chemical Impurities and Byproducts
GeMcitabine Intermediates (T6, T9, 8): They're intermediates from the synthesis of gemcitabine, an anti-most cancers drug. Their analyze is significant for optimizing the production approach and guaranteeing superior purity.
Lapatinib Intermediate (CAS NO. 231278-eighty four-five): Lapatinib is employed to deal with breast most cancers, and these intermediates are linked to its production.
Fulvestrant Intermediates: Fulvestrant is surely an estrogen receptor antagonist used in the cure of breast most cancers. Numerous intermediates assist in the synthesis of the drug.
Paclitaxel Facet Chain Acid (CAS NO. 949023-16-9): This intermediate is used in the synthesis of paclitaxel, a chemotherapy drug effective in treating cancers which include ovarian, breast, and lung most cancers.
3. Other Notable Compounds
Irinotecan Hydrochloride Trihydrate (CAS NO. 136572-09-three): A chemotherapy drug Utilized in the procedure of 5'-dibenzoate colorectal cancer and compact cell lung cancer.
3-Amino-1-hydroxyadamantane (CAS 702-eighty two-9): This compound is involved in the synthesis of adamantane derivatives, that have several apps, which includes antiviral properties.
Vildagliptin Intermediates: Utilized in the manufacture of vildagliptin, an oral drug for kind two diabetes that inhibits the enzyme DPP-four to regulate blood sugar ranges.
4. Miscellaneous Compounds
D-Gluconic Acid δ-Lactone (CAS NO. 61259-48-one): This compound is involved in the synthesis of varied gluconic acid derivatives, that are Employed in foodstuff, pharmaceutical, and industrial purposes.
Canagliflozin Intermediate 2: A CAS NO.125700-67-6 precursor from the synthesis of canagliflozin, a medication used to handle variety two diabetes by inhibiting sodium-glucose co-transporter 2 (SGLT2).